ea0021p185 | Diabetes and metabolism | SFEBES2009
Dakin Rachel
, Hadoke Patrick
, Seckl Jonathan
, Walker Brian
, Drake Amanda
Although obesity affects men and women, the risks of associated metabolic disturbances (e.g. type 2 diabetes) differ between the sexes. Altered peripheral glucocorticoid metabolism may underpin the metabolic consequences of obesity; however, most research exploring this has focused on male animals. This study used a mouse model to investigate the hypothesis that alterations in glucocorticoid metabolism caused by diet-induced obesity (DIO) will be more profound in males than in...